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Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6.

机译:人乳头瘤病毒16 E6与p53和E6AP的结合受到针对E6第二个锌结合域的单克隆抗体的损害。

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摘要

The E6 protein of cancer-associated human papillomavirus type 16 (16E6) binds to p53 and, in association with E6AP, promotes its degradation through the ubiquitin-proteasome pathway. The aim of this work was to develop monoclonal antibodies against 16E6 and to test their effect on the binding of 16E6 to p53 and E6AP, and on the degradation of p53. It was shown that an antibody directed against the N terminus of 16E6 inhibited E6AP-dependent binding to p53 and degradation of p53, whereas two different antibodies directed to the second zinc-binding domain of 16E6 reduced 16E6 E6AP-independent binding to p53 and binding to E6AP but not degradation of p53.
机译:与癌症相关的16型人类乳头瘤病毒(16E6)的E6蛋白与p53结合,并与E6AP结合,通过泛素-蛋白酶体途径促进其降解。这项工作的目的是开发针对16E6的单克隆抗体,并测试其对16E6与p53和E6AP的结合以及对p53降解的影响。结果表明,针对16E6 N末端的抗体抑制了E6AP依赖于p53的结合和p53的降解,而针对16E6第二个锌结合域的两种不同的抗体则降低了16E6 E6AP独立于p53的结合和与p53的结合。 E6AP,但不降解p53。

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